Why do I feel so unhappy, purpose-less, trapped, and insignificant?

I am 36 years old. I have a wife that I love, and that loves me. Two cool dogs. A house. My wife and I have steady jobs. I have been depressed for over 12 years since I lost both my parents. I no longer talk to anyone in my family because of some perceived issues surrounding my parents death. Sometimes I feel like I should talk to them but i feel like I've developed ignoring them as a defense mechanism and it's been so long that it would be too awkward at this point. I have been in therapy and am currently taking meds for depression but it doesn't seem all that effective. I absolutely hate my job. It is unchallenging and boring and I am vastly underpaid. Yet I can't get myself to do anything else! I am very intelligent and talented yet I feel stuck in "the comfortable of a known quantity" even though I hate it, which is very frustrating. I see alot of my friends really progressing along in their careers, making alot of money, having kids and a family, etc. and I feel like that will never be me and it makes me sad. I want to do something that I love, something that I can make a lot more money at, something that I actually find rewarding. I feel like i have no purpose in life and I am really bored of doing the same thing over and over. As bad as I feel saying it, I don't really enjoy my wife, house, dogs, etc. like I should because I am just so bored of myself and how my life is going. I wouldn't say I'm suicidal but sometimes I just can't find a reason for existing. People say that I should find reason enough in my wife, etc. but it's not enough for me, which makes me feel even worse. I feel trapped and I don't know what to do. I'm desparate. Any advice/help would be greatly appreciated. Thanks.

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