Colic or acid reflux?

What will cause a baby to not be able to sleep at night? I believe she's colic or acid reflux and the dr has put her on medicine to see if it helps. At night time the only time she will sleep is if she's in a burping position. She will not lay down and if I do she spits up and a lot of nights she's up from midnight to 6am. What does it sound like? I really want to help her because I know something bothers her at night. She 8 weeks and any info will help .plz and thank you

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